Boss: Queen Leech - first encounter | Treatment Plant Walkthrough Resident Evil Zero HD Guide

Use your best weapons to weaken the queen.

Battle with Queen Leech takes place in a large room, so your heroes will have a lot of space. It is advisable to stay on the move, because the boss is a danger only when you stand close to it or mid-range. The queen can spit acid - this attack doesn't deal a lot of damage, but being affected by acid for too long may cause you trouble.

Try to prevent the boss from catching the heroes, because they will lose a lot of HP.

A far more dangerous attack is when the queen tries to catch one of the heroes. A character that gets caught receives a lot of damage and will require immediate healing. Because of this, it is advisable to play the battle as Rebecca and try not to get too close to the monster. You should use Magnum to deal damage to the queen, but other strong weapons are also good (the boss is not particularly resistant to any of the weapons).