On this page of the guide to Spider-Man Miles Morales you will find a walkthrough of a short side mission - Matter Up. After this mission, you will receive a Programmable Matter Suit. The task can only be unlocked after neutralizing 3 Roxxon Labs and 3 Underground Hideouts.
Location: Upper West Side
Rewards: 100 XP, Programmable Matter Suit
After clearing 3 Roxxon Labs and 3 Underground Hideouts in the city, you will receive a message from a reporter about a secret hideout of Roxxon Lab members. The mission will not be available from the FNSM app - to start it, go to the marked location on the map.
Scan the surroundings when you arrive at the roof of the building. Yank the door with the web (L1 R1) and open the safe.