This page of Marvel's Spider-Man solution contains a description of Quarantine mission. The attack on the prison causes a very bad course of events - Peter has no idea that it's going to be one of the worst days in his life.
At first, fight against prisoners. They are poorly armed and quite weak, so you will manage without any problems. Over time, you will encounter more and more groups of fugitives.
After a long battle, you will learn that the prisoners are stealing a helicopter. Grab it and... Electro appears! After a vehicle breakdown, you will get to another part of the prison.
You will have to fight another wave of prisoners here. It's a good idea to use an electric web, as enemies will arrive in great numbers. After the crowd has calmed down, approach the door and open it.
This time you'll see... Rhino. All the well-known Spider-Man's enemies join the combat one by one. Run behind your opponents and walk through the damaged door, and you will come across Scorpio. Again, you have to defeat prisoners' crowds - this mission is full of fighting.
Go to the marker and run up the wall. Go through the gap in the wall and race the escaping Electro. When you catch him, Peter's next opponent will appear - Vulture.
Speed up after the enemy and enter the warehouse. Avoid electrical lightning and rush upwards, if possible jump against Electro attacks.
At the top, you will find a great cutscene - Vulture, Electro, Rhino, Scorpion and Mister Negative - have united under the leadership of Dr. Octopus and finally defeated Spiderman. Our hero will yield to their strength - the mission will end. Reward: 4000 XP.