In Red Dead Redemption 2 you can find the legendary bison, it's waiting for you near Lake Isabella.
The Bison moves within the area marked on the screen below.
Which weapon to use against the Bison?
You have to go after the bison with heavy weapon.
Rifle - you can shoot from a long distance, but you have to take many shots to kill the big animal.
Shotgun - using a rifle you have to get much closer to the bison but it is the most effective weapon.
What does the fight with the Bison look like?
The bison is a shy but not aggressive. If it notices you, it will start running away. This makes it easy to lose sight of him.
If you're close to the bison, start shooting at it quickly. This will allow you to kill it before it can escape.
What can I do with the White Bison hide?
If you go to the Trapper you can create:
Legendary White Bison Hat - bison hide and 45 dollars,
Legendary White Bison Hat - bison hide and 29 dollars
If you go to a Fence, you can craft a Bison Horn Talisman. This will regenerate your stamina 10% faster.