A truck is not a car and you have to get used to it.
First of all it does not accelerate fast (that feature depends on the engine - the more powerful the better). Therefore, be careful when coming from a road without right of way, especially where there are no traffic lights.
Second thing is the braking distance - it is very long. If you prefer to ride economically, use the exhaust brake ([B] by default). There is also a hand brake ([Space]), by default) available, but avoid using him. If the braking distance is too long, you can change it in the options.
Third thing is the trailer stability - it can be a great pain for the new players, which has been added in one of the recent updates to increase game realism. You can change in the options menu how intense it is, but if you prefer more realistic approach to the game, then you must decrease your speed before every turning.
When you drive for thousands of kilometers use a cruise control which is especially useful on highways. When your truck reaches the desired speed, e.g. 90 km/h click on a button to enable the cruise control ([C] by default). Remember that all trucks can go up to 90 km/h. The only way to make them go faster is to turn the cruise control off in the options.
The best camera to control the truck is the one located in a cabin. It is a bit awkward to drive with it through a city as you have to look around in order not to hit anything. However, on a highway the front view and mirrors are perfect. Use the real mirror on your left and a virtual one ([F2] by default) on the right (in order not to turn around all the time).