Wasteland 2 starts of 15 years after the events from the first game. In the meantime, Rangers of Wasteland abandoned Rangers Center and moved their base to Ranger Citadel - a pre-war shelter, which in the first game was the base of Guardians of the Old Order, a cult destroyed by the player's squad. Snake Vargas is now a general of Rangers of Wasteland, Angela Deth still continues her job, Thresher is a cartographer, and Razor went on a patrol a few weeks earlier and has not been seen or heard ever since.
Rangers pick up disturbing radio signals, in which a man named Mathias broadcasts suspicious deliveries about combining the man and the machine. The signal is too weak to be traced though, so Vargas sent Ace (an NPC who could be accepted to the team in the game from 1988) to mount the three repeater units at the radio towers in the area. Ace only managed to mount one unit, before dying under suspicious circumstances. The adventure begins at his funeral. The player's squad gets to finish the mission and mount the other two repeaters.