On this page of the guide, you will find a description of all the ways in which Ryan can die. Remember that the game features the "death rewind" option, which you can use if you die by accident.
Considering the content of this page, a spoiler warning is in order. Below, you will read about important choices and situations that happen during The Quarry's storyline. For obvious reasons, we had no way of avoiding spoilers, but we tried to describe the storyline as vaguely as possible, and only point to specific situations.
Chapter 10 option 1
Ryan may die at the hands of a transformed Chris after he has already killed virtually his entire family. If you don't shoot the werewolf, it will pounce on Ryan and take his life.
Chapter 10 option 2
Ryan can kill Silas if you don't kill him in the final scene. Except for Ryan, everyone in the area will die there. If you want this scene not to happen, you must let the White Wolf be shot down.