On this spoiler free page of our guide to The Last of Us 2 you will read a walkthrough of escape from school sequence. The school serves as The Wolves hideout (Seattle Day 1).
Fighting against Wolves
At the beginning, you will watch a short cutscene in which Ellie is tied up in a chair. When Dina is in danger, maneuver with your left knob to grab a piece of glass. Then, free yourself from your restraints, and quickly run to Dina in order to kill her torturer.
Now will have to confront human opponents in the game for the very first time. Human enemies are far more dangerous than Infected as they can flank you, hide behind obstacles to take cover, fight as a team, etc. In this case you are immediately detected, so run left, hide behind obstacles to get some cover and shoot at your opponents.
Renew your supplies, heal yourself if necessary, and follow Dina. Another two enemies will arrive - enter one of the rooms next door and wait until the enemy is in range. Remember that when the enemies are close enough, you can easily kill them by using your knife or other melee weapon.
After the fight, search the rooms and follow Dina. You will get to an area with thick grass that can be used as cover. Try to remain hidden as long as possible to silently eliminate the guards. After a while, another wave of enemies will appear, so watch out for ammo reserves and first aid kits.
Follow Dina and you'll get to the roof. Hide under solar panels to avoid immediate detection and once again quietly eliminate enemies.
After the fight, go to the door, search the storerooms and jump out through the window. Then jump on the adjacent balcony. Collect all supplies in the rooms, and then come out through the partly open door.
Before you move on, you can take some time to explore the area. Also, it is worth to move the container under one of the balconies, as you will find there a crafting recipe for creating mines, which are very useful against enemies.
Push the same container up to the fence to jump to the other side.
Road to the TV station
As you walk down the streets you will come across another group of Wolves, which you have to get rid of (or sneak by unnoticed).
As you continue your journey, you will come across a new group of enemies. However, in this case, there are also some infected creatures nearby - you can use this circumstances to lure two groups to fight each other, for example by throwing bottles or shooting your weapon.
Step out of the area occupied by the infected by using the garage door and you'll run into Wolves again. Try to kill one of them silently, and Dina should kill the other one that resides in the area. Then you can try to exterminate the rest of your enemies quietly, or you can take down a soldier with a rifle on top and start shooting.
Now run to the roof of the brick building where the wolf shooter was staying. Exit through a hole in the wall and continue on to the TV station.