There's an achievement in Marvel's Spider-Man, called "With great power...", which refer to the famous quote from Uncle Ben - "With great power comes great responsibility". To unlock the said trophy, you need to head to the graveyard and pay a visit to Uncle Ben's final resting place.
You'll need to get to the Harlem, to the northern corner of the district. You'll find a vast graveyard there, and your task will be to find the grave of Uncle Ben. Easier said than done, though - check out the screenshot above to learn the location of his grave.
Ben's grave is located in the middle of the graveyard, on a hill. It can be distinguished from the other graves by its appearance - it's brighter and has a readable inscription. When you approach it, Peter will be able to "talk" with his uncle, which unlocks the "With great power..." achievement.