General assumptions: You must use all two disguises available in the sixth game mission.
You can easily obtain henchman disguise, because you can encounter these characters in Orphanage Halls and Central Heating stages. So get rid of any opponent and take his clothes.
Rosewood security guard disguise can be obtained only in the Orphanage Halls stage. You can take clothes of a guard tortured on the first floor of the orphanage or from a body in the chapel on the ground floor.
General assumptions: You must find two evidences.
First evidence can be obtained in the Orphanage Halls stage. It lies on the reception table on the ground floor and unfortunately obtaining it is very hard, because you'll have to distract all nearby enemies (or get rid of them earlier).
Second evidence can be obtained in the Central Heating stage. It is located in one of side corridors on your way to the place where Wade hides. Also in this case you'll probably have to distract local enemies, but you should have no problems with that.
General assumptions: You can't be spotted. In order to complete this challenge in 100% you have to do this in each of three stages of the sixth mission. You have to really watch out only in the Orphanage Halls stage. It is best to use henchman disguise, getting consecutive fuses with proper precautions.
General assumptions: You can't use disguises (you have to stay in default priest clothes). In order to complete this challenge in 100% you have to do this in each of three stages of the sixth mission. This is unfortunately not easy challenge. You have to perfectly examine the paths and behavior of enemies. As the last resort I recommend lowering the difficulty level.
General assumptions: You have to save the Rosewood guard tortured by bandits.
An opportunity to complete this challenge appears at the very beginning of the Orphanage Halls stage, because the room with tortured guard is located in front of the starting place. You have to get rid of all local bandits, doing that before they kill a guard. Depending on your preferences you can try to attack them one by one by surprise or use the point shooting mode. You can ignore the saved guards, because you do not have to release him.
Out of Fuse
General assumptions: You must collect all fuses and use it while not being spotted. It is of course easier to complete this challenge on lower difficulty levels, especially that fuses are then hidden in less guarded places. Details on locations of fuses and where to use them can be found in walkthrough of the sixth mission.
Playing with Balls
General assumptions: Hide five enemy bodies in a container with colorful balls.
The mentioned container can be found in the Orphanage Halls stage, in the toy room on the orphanage ground floor, near the canteen. You have to hide inside 5 bodies of stunned or killed enemies.
General assumptions: Eliminate Wade without being spotted.
An opportunity to complete this challenge appears at the very end of the Central Heating stage, after reaching the place where Wade hides. DO NOT choose the main path leading to his hideout, but go to the right. You have to find a valve shown on the above screen.
After turning the valve get inside the ventilation shaft located on the right. Go to its end.
After leading the shaft start sneaking. You have to interact with another valve shown on the above screen. Wade will be eliminated and Hitman won't get spotted.
General assumptions: This challenge is automatically unlocked after completing the Rosewood mission.
Subtle Injection Part 1
General assumptions: You must stealth kill three characters with the syringe.
This challenge can be completed in the Orphanage Halls stage and you must start with finding a syringe. First syringe can be found on the first floor, near the room with tortured guard.
Second syringe can be found on the ground floor, in the medicine office.
After obtaining the syringe start using it to eliminate enemies. Theoretically you can throw them but it is much safer to use them in a close combat after getting the enemy from behind. Kill three persons in that way, remembering that you can trigger an alarm in the meantime.
Subtle Injection Part 2
General assumptions: You must stealth kill four characters with the syringe. This challenge is an extensive version of previous one.
Subtle Injection Part 3
General assumptions: You must stealth kill five characters with the syringe. This challenge is an extensive version of previous one.