Deactivate the heating
Go to the hotel. Proceed through the upper door on the left - you will reach the reception. Ring the bell. You receive the key to the room no 5. You learn that the room no 13 is haunted and that strange cult is gathering in the laundry room. Go outside and reach the floor below. Go through the door on the right. You reach the hotel's corridor. Approach the door on the right and open it with the key. Speak with Doc and Bozo. Go back to the corridor.
Go down the stairs to the ground floor. Approach the device on the right. The machine controls the heating. To deactivate it, all lights have to be blue. Do that by pressing buttons - you can use the diagonal buttons (on the right), the button on the right, in the middle, on the left and the one on the side (on the left), and the lever. The easiest way to solve this puzzle is to: click on the diagonal button, the lever, the diagonal button, the one in the middle and the one on the side (on the left). Go back to the Doc's room - Bozo still doesn't want to give you his towel. He tells you that he is hungry. You also notice signs of an illness.
Get the ingredients for "pathogenic" pie
Take the bag standing on the ground. Open it in your inventory - you will get a shampoo. Go to the reception - you meet Cletus and his robot. Go to the restaurant and replace the bag with money standing on the counter with Bozo's bag. Open it in your inventory - you will get money. Take the salt shaker and the pepper shaker (from the table). Take the cork screw from the drawer, and try to use the coffee express - you will get coffee dust.
Go back to the corridor with the hotel rooms. The first door on the left leads to the Seer's room (you may recognize him from the previous game). Speak with him. After that, take the toothpaste (the item is on the wall in the middle of the room). Go back into the corridor and then go outside. Knock on the toilet's door (located on the bottom). The man in the toilet complains about the toilet paper's quality. Give him money, and he will give you a coin. Open the door to the empty toilet and take the toilet paper. Use it to polish the coin. Pull the flusher - it is broken.
Go to the room with a pie vending machine (the same room where you deactivated the heating). Insert the coin into the vending machine. Take the pie. Open the inventory and combine the pie with the pepper shaker, toothpaste and coffee dust. You are missing one ingredient. Reach the middle floor and go through the door on the left - this is the laundry room where the aforementioned cult stays. Take Bozo's suit and a coat hanger. Leave the room.
Go to the hotel's corridor. Proceed through the last door on the left - you will meet a ghost. Speak with it. Examine the hole in the wall and click on the broken dishes (on the ground) - Rufus will get a fish knife. Go through the door on the left. Check the trash bin, use the salt shaker on the pelican, and then click on it with the coat hanger. Take a fish out of the bird's beak. Cut it with the fish knife - this will add scales to your inventory. Go to the Seer's room and throw the scales into his hood. Speak with the man, ask him what he is doing, and convince that he looks fine. The man will put the hood on. Give him Bozo's shampoo. The Seer tells you to go outside. Then, he will go take a shower.
Go back to the ghost's room, and approach the window. Go to the balcony and look through the window into the Seer's room. Take the tarantula jar. Use the cork screw to open it - the tarantula will run away. Rufus now has an empty jar and a cork. Use the cork to plug the leaking pipe. Go to the toilet and pull the flusher. Take the urinal cake from the toilet bowl. Use it on the pie and then give to Bozo. He will feel sick immediately. The man asks you to bring him clothes. Give Bozo his suit - the man will finally give you the towel.