You won't find any items here, so you may proceed towards the tomb right away. There's only one entrance (screen), so you really can't get lost. Wait for the game to display an interesting cut-scene. One of Dracula's slaves blows up the entrance to the tomb, trapping you inside. As you've probably suspected, your next big challenge will be to find an alternative exit out of the tomb. Thankfully, it's not going to be too difficult.
You'll end up standing inside a small dark room. There are some interactive objects here and it'll be up to you to collect them. Take a Plank, a Turban and a Pick head. You can also take a closer look at the skeleton and the blocked exit, however it's option. Proceed to the bottom of the screen and start moving towards a new corridor. You'll end up standing near a trap. Listen to what Van Helsing has to say about your current situation.
As you've probably noticed, there's a passageway near the spikes, however you can't reach it at the moment. Instead, choose the plank from your inventory and use it on the other side of the gap (screen). Once this is done, click on the plank and you'll reach the new area safely. There's a Lantern here. Pick it up and proceed to a new corridor.
You will come across a small junction. Start off by moving to your left. You should be able to find one collectible item here. Pick up a Belt which can be found next to a body of a young girl. You can try clicking on the door while you're at it, however you won't be able to solve this riddle at the moment. Nevertheless, examine five hotspots (a sun icon in the middle and four branches). Each time you've clicked on an interactive element, you're going to be rewarded with a short opinion stated by Van Helsing himself.
Go back to the junction. It won't come as a surprise to you that you will have to explore the right corridor. You'll end up inside an interesting room where bodies were prepared for mummification. Look at the signs above the door and examine the painting seen in the background. Now you will have to collect a few times. Pick up some Linen stripes, as well as a Flask of oil. Once this is done, go back to the corridor with the hole in the ground.
Open your inventory, because you will have to perform an important action here. Combine your newly acquired linen stripes with a turban. As a result, you will receive a rope. Activate this item and use it on the wooden plank (screen). Open the inventory once again. Use the matches to lit the lantern. After that, use the lantern on the rope. Van Helsing will automatically get down to a lower level.
You should be able to find a Spike here. Once this item is in your inventory, proceed to your right and you'll end up standing in a very small room. There are some Curious plants here and it'll be up to you to collect them. Open the inventory and combine a pick head with a spike. This will allow you to gain possession of a very useful tool. Use the pick axe on a small opening (screen).
Sadly, you'll lose your pick axe while trying to get out of the tomb. The good news is that the spike will reappear in your inventory, because this is the only item you were able to retrieve from the damaged pick axe. You'll find yourself standing outside of the tomb. Talk to the old man (screen) and he'll introduce himself to you as Herodotus. This is a very important conversation, so you shouldn't skip it. You'll find out more about the tomb and what's hidden inside it. Your next objective will be to retrieve some of the key artefacts in order to rebuild the seal. Herodotus will give you a document - Herodutus' list. This is the list of items you'll have to find before going back to the tomb. Wait for the game to transport you back to Cairo's marketplace.