This page in our guide to Devil May Cry 5 contains a description of one of the bosses in the game - the enormous Gilgamesh.
Gilgamesh in Devil May Cry 5
Where to find the boss: Mission 06 - Steel Impact
The boss is huge and it has only one weak spot - the red spot on the back. To get there, attack Gilgamesh's legs - deal enough damage to one of the spots on the legs to turn them into a Grim Grip point. Use them to launch yourself into the air and land on Gilgamesh's back.
Focus your attacks on the weak spot. Gilgamesh will shoot lasers at you and eject spikes out of its back. Avoid the boss's attacks by jumping.
The fight is rather simple - the enemy has only a few attacks. Keep attacking the weak spot and remember about avoiding attacks. If you do that, you will defeat Gilgamesh pretty fast.