Mrs. Timbol has a very important function in Shai-Gen. She recruits and trains new gang members. Eliminating her will weaken the troops protecting main boss' residence.
She now stays in her seat west from the Intellicentre Agency supply point. That's why we suggest you start your action there, Agent.
Just like in case of two preceding bosses, Timbol took a liking to the top of the building. She stays in a transparent room which you will reach from the roof. You shouldn't have much problem with jumping onto it from the neighboring buildings.
Don't bother with enemies on the roofs along the way. They can't meet your speed. Jump onto the building on the west. Don't change direction and climb on the roof of next building. Now one last jump and you will get to the glass room (check the picture below).
You will find the entrance aside the tunnel. Run through it and concentrate on eliminating the boss. Then deal with her guards.