In the game, you can obtain a plethora of items that you can use to affect your character's actions. From the inventory level, you can assign them to specific keyboard hotkeys, which makes it easier to use them. There are several items that you should have mapped to your hotkeys at all times. Health elixir is a must here, because this one is indispensable in combat. In some locations, you are exposed to poisoning, either at the hand of opponents, or as a result of poison fumes in caves. To neutralize poisoning, you can use an antidote. Also, you can use several other items that remove negative effects such as paralysis.
Apart from healing items, there are also usable items that you can use to fuse your weapons with elements, or increase ninja or samurai points. You can also map to your keyboard throwable items, such as stones or kayakudama, i.e. explosives wrapped in piece of paper. An interesting item is the Hyottoko mask, thanks to which you can spit fire at your opponents. It deals quite high damage and sets the opponent on fire, which deals additional damage.
An important element of the game, necessary for completing it, are storyline items. Most often, these are keys that open doors to the next part of the location. They are marked in blue. Usually, they are dropped by stronger opponents that are necessary to defeat to push the story forward, or to loot the chest they guard.