This is one of the toughest fights. During this one you play as Tsunade and have to beat Madara. You should equip yourself with Hero set with a lot of health potions.
During the first phase, keep attacking Madara until he loses his first health bar. Do this however you like, but do not forget to use support and ninjutsu. Try not to lose too much health in this part of the combat.
The next phase begins with a cut-scene, after which Madara jumps into a tree. Only Raikage can drag him down from there, so use him to do this as soon as his cooldown ends. When Madara falls down, attack him as quickly as possible, because he is going to jump back into tree branch. While sitting there he is using the wood style - you cannot respond to that otherwise than with dodging his attacks. At least he jumps off after several attacks. Before this phase ends you should heal up.
Two more health bars down, and Madara summons Susano. You will have to decide whether to stand to the fight against him without your ability to heal but with a help from your support, or the other way round. As the fight begins, the new opponent showers you with punches. You can block fire balls, however, do not try this against sword strikes - rather dodge these. To get your own back, you will first have to destroy the six seals on his chest.
You can use the help from your support, if you have it. Otherwise you will have to do this on your own. The best way to do that is with hand to hand attacks.
When you have broken the seals, keep pressing the attack button, to deal damage. You will need to repeat this pattern several times until his last health bar drops to half - then the final quick time event starts.
Secret Factor: 35 stars.