You start exploring Seattle in Queen Anne district and do not worry that initially you can't use any powers. Follow Reggie to the east, reaching D.U.P. Scanning Station after a while. Go through the gate, wait until Reggie gets checked and position yourself at the scanner. Press touchpad and move your finger to hit the red circle. Unfortunately you won't be able to enter Seattle even if you succeed in this mini-game because you'll be recognized as a bio-terrorist.
Right after the fight begins jump over the gate and start attacking nearby D.U.P. soldiers. I recommend using mainly standard projectiles (Smoke Shots), although if you find yourself close to the enemy, then consider using the chain or melee. In the same time do not overdo with aggressive behavior and as soon as you get a warning about serious injuries use Smoke Dash to get away to some safe place and regenerate health. On the other side try not to stop in the same place for a longer period of time because enemies throw grenades and you can get seriously injured.
During the fights near scanning station you'll get a possibility of getting Karma points. If you want to acquire Good Karma then you can free prisoners kept in cages (use touchpad when you get close to the cage), as well as overpower defeated enemies and save injured civilians. If you want to get Bad Karma, you can finish off defeated D.U.P. soldiers and murder innocent civilians.
Keep moving to the east and prepare to face new enemies occupying watchtowers visible in the distance and a catwalk between them. You can still try to use standard projectiles here (destroy parked cars and absorb smoke when needed) but this is not the most efficient method. I recommend bouncing from one of the cars in order to get to one of towers or (even better idea) destroy both towers thanks to Cinder Blast power.
After eliminating all enemies listen to the radio conversation with Reggie and choose the street leading north. Watch out for the single sniper observing this area. Since there are no places to hide here, it is best to eliminate the opponent with perfectly aimed projectiles. Keep moving north and then turn east again. After few moments the man hero will approach enemy base. I recommend using Smoke Dash when you get close to one of ventilation shafts, so after moving to the roof you can familiarize yourself with enemy base settings. This is quite helpful because the area is restricted and entering it will result in alarming enemies.
Try to attack enemies from the air if possible, so you can initially get rid of at least one of them. When the main part of the battle begins, watch out for enemies on watchtowers (you can destroy them). In addition try to rely on Smoke Dash attack, running between obstacles and looking for good places to attack enemies. When you run out of smoke use red ventilation shafts to get to base roofs - on majority of them you can find kind of chimneys where you can regenerate your supplies.
Once you eliminate all enemies in the base go towards the Mobile Command Centre. Start using standard projectiles to destroy side grilles and generator behind them. After destroying a sufficient number of generators jump to the vehicle roof and position yourself next to the large core. Press and hold touchpad and then start rhythmically pressing R2, blowing the mobile command centre up.
Prepare for a new group of D.U.P. soldiers appearing in the area, with a single elite opponent who uses minigun. I recommend avoiding this character initially and get rid of all standard soldiers first. After that you can deal with the elite one. Do not try to weaken him down in a melee because you can get pushed off easily. Instead of that attack him from a distance with standard Smoke Shots or more powerful Cinder Blast. Do not forget about possibility of smoke regeneration on rooftops.
After taking some damage the elite soldier will create some king of a shield. Run towards him from behind (screen above) and depending on your preferences subdue him (triangle button) or kill him (square). That's not all yet because Delsin has to absorb his power - you can do this by standing next to the defeated soldier and pressing touchpad.
Soon, you will be informed that the first main mission in Seattle has just been completed. As a reward for its completion:
- The Catching Smoke mission unlocks
- Side activities in Queen Anne district unlock
- Information on the whereabouts of the Blast Shards, on the main map, in Queen Anne are added
Note - To find more information on the activities to be performed in the city and on capturing districts, see the chapter entitled The City and the inFamous: Second Son in 10 easy steps guide.